Scopri l'Aloe Vera con MondoAloe.IT
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Ricerche e Brevetto dell'Università di Padova
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ATTENZIONE: Leggi attentamente le avvertenze
L'Aloe è da sempre impiegata dall'uomo per i suoi molteplici effetti benefici. Per questa pianta, come per altre, il presunto effetto anti-cancro era stato dichiarato più volte ma sino a poco tempo fa, non erano emersi studi che rispondessero a severi criteri scientifici e che dimostrassero una sua efficacia sull'uomo.
Nelle ricerche condotte dalla Dott.ssa Teresa Pecere e il suo gruppo, nel laboratorio diretto dal Prof. Giorgio Palù, ed in collaborazione con il Prof. Modesto Carli, del Dipartimento di Pediatria, AE (aloe-emodina) si è dimostrata molto attiva contro le cellule dei tumori che originano dal sistema nervoso autonomo, cioè quello che innerva tutti gli organi del nostro corpo, quali il melanoma, il tumore a piccole cellule del polmone e neuroblastoma.
Il neuroblastoma è un tumore che colpisce solo i bambini ed è la prima causa di morte in età prescolare nel mondo industrializzato. Nelle ricerche della Dott.ssa Teresa Pecere su cellule coltivate in laboratorio è stato dimostrato che AE "seleziona" le cellule da colpire (quelle del neuroblastoma, in particolare) e non aggredisce le cellule sane. Questo significa che questa molecola è "tumore-specifica", cioè colpisce solamente le cellule del tumore e risparmia le cellule sane, ma in rapida replicazione come le cellule del tratto gastro-intestinale e del midollo osseo.
Una volta dimostrata la selettività d'azione in vitro, gli studi proseguirono sugli animali da laboratorio. Nei topi AE ha dimostrato una buona farmacocinetica, la capacità di bloccare la crescita del tumore unita ad una scarsa tossicità. Con queste ricerche, isolando antroni e antrachinoni (aloe-emodina, emodina, crisofenolo e diversi altri), presenti nell'aloina, si è dimostrato che i principi attivi contenuti nell'aloe si accumulano nelle cellelule tumorali, aggredendo selettivamente le cellule malate.
La notizia ha destato l'interesse del mondo scientifico, così tanto da fondare A.R.A. (Associazione Ricerca Aloe), con l'intento di studiare questa pianta ed i suoi effetti terapeutici nella lotta contro i tumori.
A.R.A. è presieduta dal professor Roberto Miccinilli, che da oltre venti anni si occupa di omeopatia all'Università di Londra. Il professor Giuseppe D'Alessio, direttore del Dipartimento di Chimica Organica e Biologica dell'Università Federico II di Napoli, ha effettuato, per conto dell'associazione, alcune ricerche sugli effetti dell'Aloe Arborescens. Testata più volte, l'aloe ha dimostrato di essere in grado di aggredire le cellule tumorali, preservando nel contempo quelle sane. A conferma di questi dati, il ricercatore americano David Hudson ha scoperto che uno stato particolare, monoatomico, di rodio e iridio possiede notevoli facoltà terapeutiche, che si sono dimostrate efficaci in casi di cancro.
Una sua ricerca ha dimostrato che tali sostanze sono presenti in notevoli quantità nell'Aloe Arborescens.
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Di seguito due documenti che evidenziano che l'aloe-emodina induce l'apoptosi delle cellule malate in vari tipi di cancro.
- "Aloe Emodin apoptosis in human epatoma", Po-Lin Kuo(a), Ta-Chen Lin(b), Chun-Ching Lin(a), (a) Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC - (b) Department of Pharmacy, Ta-Jen Institute of Technology, Ping-Tung 907, Taiwan, ROC
- "Aloe Emodin induces apoptosis in human carcinoma", Hong-Zin Lee, School of Pharmacy, China Medical College, 91, Hsueh-Shih Road, Taichung, 404, Taiwan
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Un articolo scritto dalla Dott.ssa Teresa Pecere, intitolato "Alla ricerca di nuovi farmaci", che spiega il proprio lavoro di ricerca [Leggi l'articolo]
- Formazione dell'accordo di licenza BIOLPOLIS S.p.A., Sole24 Ore, 12/03/2002
- Dettagli sul brevetto dell'Università di Padova
- Scioglimento consensuale dell'accordo di licenza BIOLPOLIS S.p.A. per lo sfruttamento dei brevetti "Impiego dell'Aloe-emodin nel trattamento di patologie neoplastiche di origine neuroectodermica" e "Derivati dall'Aloe-emodina nel trattamento di patologie neoplastiche"
Lista delle sperimentazioni
Pubblicazioni MEDLINE EXPRESS
Click per accedere alla paginaAloe-emodin Is a New Type of Anticancer Agent with Selective Activity against Neuroectodermal Tumors
Autori: Teresa Pecere, M. Vittoria Gazzola, Carla Mucignat, Cristina Parolin, Francesca Dalla Vecchia, Andrea Cavaggioni, Giuseppe Basso, Alberto Diaspro, Benedetto Salvato, Modesto Carli and Giorgio Palù
Dipartimento: Department of Histology, Microbiology, and Medical Biotechnologies, Medical School [T. P., C. P., G. P.], Division of Oncology and Hematology, Department of Pediatrics, Medical School [M. V. G., G. B., M. C.], Department of Human Anatomy and Physiology, Medical School [C. M., A. C.], and Department of Biology [F. D. V., B. S.], University of Padova, 35100 Padova and Istituto Nazionale Fisica della Materia and Department of Physics, University of Genova, 16146 Genova [A. D.], Italy
Articolo:
Hydroxyanthraquinones as Tumor Promoters: Enhancement of Malignant Transformation of C3H Mouse Fibroblasts and Growth Stimulation of Primary Rat Hepatocytes
Autori: Detlef Wölfle2, Christoph Schmutte, Johannes Westendorf and Hans Marquardt
Dipartimento: Department of Toxicology, University of Hamburg Medical School, D-2000 Hamburg 13, Federal Republic of Germany
Articolo:
Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
PMID: 11867195
Autori: Furukawa F, Nishikawa A, Chihara T, Shimpo K, Beppu H, Kuzuya H, Lee IS, Hirose M. Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, 158-8501, Tokyo, Japan
Articolo:
The effect of aloe emodin on the proliferation of a new merkel carcinoma cell line.
PMID: 11803275
Autori: Wasserman L, Avigad S, Beery E, Nordenberg J, Fenig E. Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center Beilinson Campus, Petah Tikva 49100, Israel. yardenam@clalit.org.ie
Articolo:
Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. natalensis Berger.
PMID: 11746864
Autori: Shimpo K, Chihara T, Beppu H, Ida C, Kaneko T, Nagatsu T, Kuzuya H. Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie 514-1296, Japan.
Articolo:
Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
PMID: 11730720
Autori: Lee HZ, Hsu SL, Liu MC, Wu CH. School of Pharmacy, China Medical College, 91, Hsueh-Shih Road, Taichung, 404, Taiwan. hong@mail.cmc.edu.tw
Articolo:
Cytotoxic and DNA damage-inducing activities of low molecular weight phenols from rhubarb.
PMID: 11724365
Autori: Shi YQ, Fukai T, Sakagami H, Kuroda J, Miyaoka R, Tamura M, Yoshida N, Nomura T. School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.
Articolo:
Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.
PMID: 11682458
Autori: Lee HZ. School of Pharmacy, China Medical College, 91 Hsueh-Shih Road, Taichung, 404, Taiwan. hong@mail.cmc.edu.tw
Articolo:
Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice.
PMID: 11185732
Autori: Singh RP, Dhanalakshmi S, Rao AR. Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Articolo:
Studies of aloe. VI. Cathartic effect of isobarbaloin.
PMID: 9853419
Autori: Ishii Y, Takino Y, Toyo'oka T, Tanizawa H. School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Articolo:
Induction of apoptosis in human leukaemic cell lines K562, HL60 and U937 by diethylhexylphthalate isolated from Aloe vera Linne.
PMID: 11007077
Autori: Lee KH, Hong HS, Lee CH, Kim CH. Animal Resource Research Center, Konkuk University, Seoul, Korea.
Articolo:
Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne.
PMID: 10864149
Autori: Lee KH, Kim JH, Lim DS, Kim CH. Animal Resource Research Center, Konkuk University, Seoul, Korea.
Articolo:
Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors.
PMID: 10850417
Autori: Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD, Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M, Palu G. Department of Histology, Microbiology, and Medical Biotechnologies, Medical School, University of Padova, Italy.
Articolo:
Adverse and beneficial effects of plant extracts on skin and skin disorders.
PMID: 11482001
Autori: Mantle D, Gok MA, Lennard TW. Department of Surgery, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU.
Articolo:
Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells.
PMID: 11460308
Autori: Lee JK, Lee MK, Yun YP, Kim Y, Kim JS, Kim YS, Kim K, Han SS, Lee CK. College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea.
Articolo:
Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan.
PMID: 1910624
Autori: Peng SY, Norman J, Curtin G, Corrier D, McDaniel HR, Busbee D. Department of Anatomy, College of Veterinary Medicine, Texas A & M University, College Station 77843.
Articolo:
The therapeutic potential of Aloe Vera in tumor-bearing rats.
PMID: 10093794
Autori: Corsi MM, Bertelli AA, Gaja G, Fulgenzi A, Ferrero ME. Institute of General Pathology, Medical Faculty, University of Milan, Italy.
Articolo:
Aloe vera: a systematic review of its clinical effectiveness.
PMID: 10885091
Autori: Vogler BK, Ernst E. Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter.
Articolo:
Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study.
PMID: 8765459
Autori: Syed TA, Ahmad SA, Holt AH, Ahmad SA, Ahmad SH, Afzal M. Department of Clinical Physiology, Malmo University Hospital, Sweden.
Articolo:
Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models.
PMID: 11268118
Autori: Okyar A, Can A, Akev N, Baktir G, Sutlupinar N. Department of Pharmacology, Faculty of Pharmacy, University of Istanbul, 34452 Universite, Istanbul, Turkey.
Articolo:
The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats.
PMID: 1842751
Autori: al-Awadi F, Fatania H, Shamte U. Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat.
Articolo:
Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride.
PMID: 11129503
Autori: Arosio B, Gagliano N, Fusaro LM, Parmeggiani L, Tagliabue J, Galetti P, De Castri D, Moscheni C, Annoni G. Department of Internal Medicine, Milano University Study and Hospital Maggiore IRCCS, Italy.
Articolo:
Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat.
PMID: 9834927
Autori: Shamaan NA, Kadir KA, Rahmat A, Ngah WZ. Department of Biochemistry and Microbiology, Universiti Putra Malaysia, Selangor, Malaysia.
Articolo:
Decreased levels of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts in rats treated with beta-carotene, alpha-tocopherol and freeze-dried aloe.
PMID: 8641964
Autori: Uehara N, Iwahori Y, Asamoto M, Baba-Toriyama H, Iigo M, Ochiai M, Nagao M, Nakayama M, Degawa M, Matsumoto K, Hirono I, Beppu H, Fujita K, Tsuda H. Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
Articolo:
Inhibition of benzo[a]pyrene-DNA adduct formation by Aloe barbadensis Miller.
PMID: 9111213
Autori: Kim HS, Lee BM. Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University, Suwon City, Kyunggi-Do, South Korea.
Articolo:
The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats.
PMID: 1842751
Autori: al-Awadi F, Fatania H, Shamte U. Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat.
Articolo:
Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms.
PMID: 9789122
Autori: Lissoni P, Giani L, Zerbini S, Trabattoni P, Rovelli F. Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy.
Articolo:
Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
PMID: 11867195
Autori: Furukawa F, Nishikawa A, Chihara T, Shimpo K, Beppu H, Kuzuya H, Lee IS, Hirose M. Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Articolo:
The plant kingdom as a source of anti-ulcer remedies.
PMID: 11113992
Autori: Borrelli F, Izzo AA. Department of Experimental Pharmacology, University of Naples 'Federico II', via D. Montesano 49, 80131 Naples, Italy.
Articolo:
Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial.
PMID: 10326343
Autori: Thomas DR, Goode PS, LaMaster K, Tennyson T. Department of Internal Medicine, St. Louis University, MO, USA.
Articolo:
The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy.
PMID: 11338761
Autori: Olsen DL, Raub W Jr, Bradley C, Johnson M, Macias JL, Love V, Markoe A. Sylvester Comprehensive Cancer Center, University of Miami, USA.
Articolo:
Studies on chemical radioprotectors against X-irradiation used by soft X-ray accelerator
PMID: 7699579
Autori: Shinoda M. Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Articolo:
Acemannan-containing wound dressing gel reduces radiation-induced skin reactions in C3H mice.
PMID: 7607925
Autori: Roberts DB, Travis EL. Department of Experimental Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Articolo:
Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity.
PMID: 11262067
Autori: Pugh N, Ross SA, ElSohly MA, Pasco DS. Department of Pharmacognosy, National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677, USA.
Articolo:
In vivo metabolism of aloemannan.
PMID: 10418327
Autori: Yagi A, Nakamori J, Yamada T, Iwase H, Tanaka T, Kaneo Y, Qiu J, Orndorff S. Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan. yagi@fupharm.fukuyama-u.ac.jp
Articolo:
Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components.
PMID: 10408627
Autori: Lee CK, Han SS, Shin YK, Chung MH, Park YI, Lee SK, Kim YS. College of Pharmacy, Chungbuk National University, Cheongju, South Korea. cklee@cbucc.chungbuk.ac.kr
Articolo:
Aloe barbadensis extracts reduce the production of interleukin-10 after exposure to ultraviolet radiation.
PMID: 9579551
Autori: Byeon SW, Pelley RP, Ullrich SE, Waller TA, Bucana CD, Strickland FM. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.
Articolo:
Prevention of ultraviolet radiation-induced suppression of accessory cell function of Langerhans cells by Aloe vera gel components.
PMID: 9403333
Autori: Lee CK, Han SS, Mo YK, Kim RS, Chung MH, Park YI, Lee SK, Kim YS. College of Pharmacy, Chungbuk National University, Cheongju, South Korea.
Articolo:
Hematopoietic augmentation by a beta-(1,4)-linked mannan.
PMID: 9003464
Autori: Egger SF, Brown GS, Kelsey LS, Yates KM, Rosenberg LJ, Talmadge JE. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5660, USA.
Articolo:
Prevention of ultraviolet radiation-induced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract.
PMID: 7906286
Autori: Strickland FM, Pelley RP, Kripke ML. Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Articolo:
Anthraquinones in Rheum palmatum and Rumex dentatus (Polygonaceae), and phorbol esters in Jatropha curcas (Euphorbiaceae) with molluscicidal activity against the schistosome vector snails Oncomelania, Biomphalaria and Bulinus.
PMID: 9472303
Autori: Liu SY, Sporer F, Wink M, Jourdane J, Henning R, Li YL, Ruppel A. Institute of Tropical Hygiene and Public Health, University, Heidelburg, Germany.
Articolo:
The wound-healing effect of a glycoprotein fraction isolated from aloe vera.
PMID: 11703278
Autori: Choi SW, Son BW, Son YS, Park YI, Lee SK, Chung MH. Department of Pharmacology, Seoul National University College of Medicine, Seoul 110-799, Korea.
Articolo:
Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats.
PMID: 10808702
Autori: Somboonwong J, Thanamittramanee S, Jariyapongskul A, Patumraj S. Department of Physiology, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.
Articolo:
Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats.
PMID: 9854430
Autori: Chithra P, Sajithlal GB, Chandrakasan G. Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai, India.
Articolo:
Influence of aloe vera on the healing of dermal wounds in diabetic rats.
PMID: 9507904
Autori: Chithra P, Sajithlal GB, Chandrakasan G. Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai, India.
Articolo:
Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats.
PMID: 9507902
Autori: Chithra P, Sajithlal GB, Chandrakasan G. Department of Biochemistry, Central Leather Research Institute, Madras, India.
Articolo:
Effect of the combination of Aloe vera, nitroglycerin, and L-NAME on wound healing in the rat excisional model.
PMID: 9395704
Autori: Heggers JP, Elzaim H, Garfield R, Goodheart R, Listengarten D, Zhao J, Phillips LG. University of Texas Medical Branch, Galveston, USA.
Articolo:
Beneficial effect of Aloe on wound healing in an excisional wound model.
PMID: 9395659
Autori: Heggers JP, Kucukcelebi A, Listengarten D, Stabenau J, Ko F, Broemeling LD, Robson MC, Winters WD. University of Texas Medical Branch, Galveston, USA.
Articolo:
Isolation and characterization of the glycoprotein fraction with a proliferation-promoting activity on human and hamster cells in vitro from Aloe vera gel.
PMID: 9063091
Autori: Yagi A, Egusa T, Arase M, Tanabe M, Tsuji H. Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.
Articolo:
Hematopoietic augmentation by a beta-(1,4)-linked mannan.
PMID: 9003464
Autori: Egger SF, Brown GS, Kelsey LS, Yates KM, Rosenberg LJ, Talmadge JE. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5660, USA.
Articolo:
Studies on optimal dose and administration schedule of a hematopoietic stimulatory beta-(1,4)-linked mannan.
PMID: 8799361
Autori: Egger SF, Brown GS, Kelsey LS, Yates KM, Rosenberg LJ, Talmadge JE. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5660, USA.
Articolo:
Effect of aloe vera gel to healing of burn wound a clinical and histologic study.
PMID: 7561562
Autori: Visuthikosol V, Chowchuen B, Sukwanarat Y, Sriurairatana S, Boonpucknavig V. Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Articolo:
Treatment of experimental frostbite with pentoxifylline and aloe vera cream.
PMID: 7772322
Autori: Miller MB, Koltai PJ. Division of Otolaryngology, Albany (NY) Medical College, USA.
Articolo:
Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation.
PMID: 7853156
Autori: Davis RH, DiDonato JJ, Johnson RW, Stewart CB. Pennsylvania College of Podiatric Medicine, Philadelphia.
Articolo:
Anti-inflammatory and wound healing activity of a growth substance in Aloe vera.
PMID: 8169808
Autori: Davis RH, Donato JJ, Hartman GM, Haas RC. Department of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia.
Articolo:
Effect of aloe-emodin on expression of proliferating cell nuclear antigen of vascular smooth muscle cells in culture after arterial injury.
PMID: 11780429
Autori: Xu C, Yin C, Wang S. Department of Cardiology, PeoplÈs Hospital, Beijing Medical University, Beijing 100044, China.
Articolo:
Effect of aloe-emodin on proliferation of vascular smooth muscle cells after arterial injury
PMID: 11477819
Autori: Yin C, Xu C. PeoplÈs Hospital, Beijing Medical University, Beijing 100044.
Articolo:
Aloe vera and the inflamed synovial pouch model.
PMID: 1578350
Autori: Davis RH, Stewart GJ, Bregman PJ. Pennsylvania College of Podiatric Medicine, Philadelphia.
Articolo:
Efficacy of crude extract of Aloe secundiflora against Salmonella gallinarum in experimentally infected free-range chickens in Tanzania.
PMID: 11849835
Autori: Waihenya RK, Mtambo MM, Nkwengulila G, Minga UM. Department of Zoology and Marine Biology, University of Dar Es Salaam, P.O. Box 35064, Dar Es Salaam, Tanzania
Articolo:
Evaluation of the efficacy of the crude extract of Aloe secundiflora in chickens experimentally infected with Newcastle disease virus.
PMID: 11849832
Autori: Waihenya RK, Mtambo MM, Nkwengulila G. Department of Zoology and Marine Biology, University of Dar es Salaam, PO Box 35064, Dar es Salaam, Tanzania
Articolo:
Aloe polymannose enhances anti-coxsackievirus antibody titres in mice.
PMID: 10861969
Autori: Gauntt CJ, Wood HJ, McDaniel HR, McAnalley BH. Department of Microbiology, University of Texas Health Science Center at San Antonio Texas, 7703 Floyd Curl Drive, San Antonio, TX 78284-7758, USA.
Articolo:
Lichen planus--report of successful treatment with aloe vera.
PMID: 10687438
Autori: Hayes SM.
Articolo:
The action of an aqueous extract of Aloe barbadensis Miller in an in-vitro culture of Trichomonas vaginalis]
PMID: 9813472
Autori: Rojas L, Matamoros M, Garrido N, Finlay C. Instituto de Medicina Tropical Pedro Kouri.
Articolo:
Inactivation of enveloped viruses by anthraquinones extracted from plants.
PMID: 1810179
Autori: Sydiskis RJ, Owen DG, Lohr JL, Rosler KH, Blomster RN. Department of Microbiology, University of Maryland, Baltimore 21201.
Articolo:
In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera.
PMID: 10708884
Autori: Djeraba A, Quere P. INRA, Virologie Aviaire et Oncologie, Station de Pathologie Aviaire et Parasitologie, 37 380, Nouzilly, France.
Articolo:
In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).
PMID: 10426820
Autori: Kim HS, Kacew S, Lee BM. Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Changan-ku, Chunchun-dong, Kyunggi-do, Suwon 440-746, Korea.
Articolo:
Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel.
PMID: 8956975
Autori: Zhang L, Tizard IR. Department of Veterinary Pathobiology, Texas A & M University College Station 77843, USA.
Articolo:
Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera.
PMID: 7558512
Autori: Karaca K, Sharma JM, Nordgren R. University of Minnesota, College of Veterinary Medicine, Department of Pathobiology, St Paul 55108, USA.
Articolo:
Isolation of a stimulatory system in an Aloe extract.
PMID: 1748962
Autori: Davis RH, Parker WL, Samson RT, Murdoch DP. Pennsylvania College of Podiatric Medicine, Philadelphia 19107.
Articolo:
Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast cells activated with specific antigen-antibody reactions.
PMID: 10604937
Autori: Ro JY, Lee BC, Kim JY, Chung YJ, Chung MH, Lee SK, Jo TH, Kim KH, Park YI. Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea. JYRO426@yumc.yonsei.ac.kr
Articolo:
Initial characterization of the effects of Aloe vera at a crayfish neuromuscular junction.
PMID: 10548750
Autori: Friedman RN, Si K. Section of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202-5112, USA. rfriedma@iupui.edu
Articolo:
Antiinflammatory activity of Muktashukti bhasma.
PMID: 10356960
Autori: Chauhan O, Godhwani JL, Khanna NK, Pendse VK. Department of Pharmacology and Experimental Therapeutics, Dr. Sampurnanand Medical College, Jodhpur, India.
Articolo:
Antiinflammatory activity of extracts from Aloe vera gel.
PMID: 9121170
Autori: Vazquez B, Avila G, Segura D, Escalante B. Laboratory of Pharmacology, Escuela Nacional de Estudios Profesionales Iztacala (E.N.E.P-I), Universidad Nacional Autonoma de Mexico, Tlalnepantla, Mexico.
Articolo:
Antiinflammatory C-glucosyl chromone from Aloe barbadensis.
PMID: 8778246
Autori: Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, Weintraub ST. Department of Pharmacology, Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284-7760, USA.
Articolo:
Isolation of a stimulatory system in an Aloe extract.
PMID: 1748962
Autori: Davis RH, Parker WL, Samson RT, Murdoch DP. Pennsylvania College of Podiatric Medicine, Philadelphia 19107.
Articolo:
The isolation of an active inhibitory system from an extract of aloe vera.
PMID: 2061823
Autori: Davis RH, Parker WL, Samson RT, Murdoch DP. Pennsylvania College of Podiatric Medicine, Philadelphia 19107.
Articolo:
Phenolic constituents of Cassia seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus.
PMID: 10478467
Autori: Hatano T, Uebayashi H, Ito H, Shiota S, Tsuchiya T, Yoshida T. Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Articolo:
Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori.
PMID: 9525111
Autori: Wang HH, Chung JG, Ho CC, Wu LT, Chang SH.
Articolo:
Antifungal activity of anthraquinone derivatives from Rheum emodi.
PMID: 10967452
Autori: Agarwal SK, Singh SS, Verma S, Kumar S. Central Institute of Medicinal and Aromatic Plants, P.O.-CIMAP, Lucknow 226 015, India.
Articolo:
Antifungal effects of different plant extracts and their major components of selected aloe species.
PMID: 10441780
Autori: Ali MI, Shalaby NM, Elgamal MH, Mousa AS. Botany Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
Articolo:
Saprophytic and cycloheximide resistant fungi isolated from golden hamster.
PMID: 9768288
Autori: Bagy MM, el-Shanawany AA, Abdel-Mallek AY. Department of Botany, Faculty of Science, Assiut University, Egypt.
Articolo:
Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan.
PMID: 9278177
Autori: Stuart RW, Lefkowitz DL, Lincoln JA, Howard K, Gelderman MP, Lefkowitz SS. Department of Biological Sciences, Texas Tech University, Lubbock 79409, U.S.A.
Articolo:
The effectiveness and acceptance of a medical device for the treatment of aphthous stomatitis. Clinical observation in pediatric age
PMID: 10829589
Autori: Andriani E, Bugli T, Aalders M, Castelli S, De Luigi G, Lazzari N, Rolli GP. Servizio Medicina di Base, Istituto per la Sicurezza Sociale Repubblica di S. Marino.
Articolo:
Oxoaporphine alkaloids and quinones from Stephania dinklagei and evaluation of their antiprotozoal activities.
PMID: 10909274
Autori: Camacho MR, Kirby GC, Warhurst DC, Croft SL, Phillipson JD.
Articolo:
Isolation and identification of a phenolic antioxidant from Aloe barbadensis.
PMID: 11281293
Autori: Lee KY, Weintraub ST, Yu BP. Department of Food and Nutrition, Ho Seo University, Asan, Chungmam, Korea.
Articolo:
Antioxidant and radical scavenging effects of anthraquinones and anthrones.
PMID: 8234446
Autori: Malterud KE, Farbrot TL, Huse AE, Sund RB. Department of Pharmacognosy, University of Oslo, Norway.
Articolo:
Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice.
PMID: 11185732
Autori: Singh RP, Dhanalakshmi S, Rao AR. Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Articolo:
Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.
PMID: 8234430
Autori: Siegers CP, Siemers J, Baretton G. Institutes of Toxicology, Medical University of Lubeck, FRG.
Articolo:
The genotoxicity status of senna.
PMID: 8234427
Autori: Heidemann A, Miltenburger HG, Mengs U. CCR Cytotest Cell Research, Rossdorf, FRG.
Articolo:
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